CD8 anticorps

N° du produit ABIN5691089

Cet anticorps anti-CD8 est un anticorps Souris Monoclonal détectant CD8 dans FACS, IHC (fro), ELISA et ICC. Adapté pour Humain.

Aperçu rapide pour CD8 anticorps (ABIN5691089)

Antigène: CD8

Reactivité: Humain

Hôte: Souris

Clonalité: Monoclonal

Conjugué: Cet anticorp CD8 est non-conjugé

Application: Flow Cytometry (FACS), Immunohistochemistry (Frozen Sections) (IHC (fro)), ELISA, Immunocytochemistry (ICC)

Clone: RIV11

Détail du produit anti-CD8 anticorps

Specificité: The antibody RIV11 is directed against human CD8 and recognises all CD8 positive T-cells, thymocytes and natural killer cells.

Immunogène: RIV11 is a mouse monoclonal IgG1 antibody derived by fusion of 653 mouse myeloma cells with splenocytes from a BALB/c mouse immunized with human peripheral blood lymphocytes.

Isotype: IgG1

Information d'application

Indications d'application: The RIV11 antibody is suitable for the detection of total CD8 by flow cytometry and ELISA. The antibody is also suitable for the detection of CD8 by immunocytochemistry and immunohistochemistry on frozen tissues. Human lymph node, spleen and peripheral blood lymphocytes are suitable for use as positive controls. Optimal antibody dilutions for the different applications should be determined by titration.

Restrictions: For Research Use only

Stockage

Buffer: Each vial contains 500 μL 0.2 mg/mL purified monoclonal antibody in phosphated buffered saline (PBS) containing 50 % glycerol + 0.2 % bovine serum albumin (BSA) + 0.02 % sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Store at 4°C, or in small aliquots at -20°C.

Détails sur CD8

Antigène: CD8

Autre désignation: CD8

Sujet: CD8 is a 32 kDa cell surface transmembrane glycoprotein expressed by most thymocytes, a subpopulation of mature peripheral blood T-cells and natural killer (NK) cells. CD8 is expressed on the cell surface as a heterodimer, comprising two distinct disulphide linked α and β polypeptide chains, or as a CD8α homodimer. The CD8 αβ heterodimer is expressed on T-cell receptor (TCR) αβ+ cytotoxic T-lymphocytes (CTL's), whereas CD8α homodimers are expressed on TCR γδ+ T-cells, natural killer cells and a subpopulation of TCR αβ+ T-cells. The CD8 Molecule functions as a co-receptor (with the T-cell receptor) as part of the antigen-recognition complex on TCRαβ+, class I MHC-restricted T cells and plays an important role in T-cell signaling. The CD8 Ig-like domain binds to the alpha-3 domain of MHC-Class 1.

UniProt: P01732